Sathish and shayeda abstract patches of cyproheptadine hydrochloride cph which is a sedating antihistamine with antimuscarinic, serotoninantagonist, and calciumchannel blocking action. Mucoadhesive buccal patches of atenolol for local delivery of the drug to the oral cavity were formulated by solvent casting technique. Formulation and evaluation of mucoadhesive buccal films of. Literature studies on preparation and evaluation of buccal. Patches also ensure more accurate dosing of the drug compared to gels and ointments. Formulation and evaluation of mucoadhesive buccal patch of.
Formulation and in vitro evaluation of xanthan gumbased. Thereby, such methods may effectively contribute to the development of a sustained and targeted delivery system for drugs designed for tissues in the. Formulation and evaluation of buccal patches of diclofenac sodium. To develop mucoadhesive patches for buccal administration of metoprolol succinate and to evaluate their in vitro and in vivo bioadhesion. The thinnest formulation was cv1 and the thickest being cv4. Feb 02, 2018 evaluation of buccal drug delivery system 1. The invitro permeation study was carried out using a transdiffusion cell. Formulation and in vitro evaluation of xanthan gumbased bilayered mucoadhesive buccal patches of zolmitriptan 1. Aceclofenac containing mucoadhesive buccal patches were prepared by solvent evaporation method. Formulation and evaluation of mucoadhesive buccal patches of dimenhydrinate a dissertation submitted to the tamilnadu dr. The polymeric membrane acts as the rate controlling membrane. All the patches were uniform and translucent, having good strength, and smooth surface.
Formulation and evaluation of mucoadhesive buccal patches of. Results have shown that prochlorperazine maleate could permeate through human buccal membrane and hence showing a scope for development of buccal dosage form for prochlorperazine. Formulation and evaluation of a bioadhesive patch for buccal. The thickness of the prepared patches was in the range of 0. Mean weight was then calculated for each formulation nafee, 2003. Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon 889. The formulations were tested for in vitro drug permeation studies. It may be concluded that mucoadhesive buccal patch of ramipril is an alternate way to bypass hepatic first pass metabolism therefore it is expected to improve the bioavailability of ramipril. Research paper formulation and evaluation of pimozide buccal. The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of ondansetron hydrochloride ond which is used for nausea. Formulation and evaluation of metformin hydrochloride buccal.
Formulation, development and invitro evaluation of mucoadhesive buccal patches of methotrexate. Nagar, bangalore, karnataka, india 2accenture pharmaceutical services, bangalore, india. Formulation, development and invitro evaluation of. Cell necrosis was not observed and hence it can be concluded that, formulation containing 4% dmso is safe for buccal administration of zmt through mucoadhesive patches. For evaluation of patch weight, three patches of each formulation were individually weighed on a digital balance atx 224, shimadzu, japan. Design and evaluation of tizanidine buccal mucoadhesive patches and p. The results indicate that the mucoadhesive buccal patches of naproxen may be a good choice to bypass the undesirable systemic side effects and can be proposed as a new therapeutic tool against dental and buccal inflammatory diseases and disturbs. Citeseerx document details isaac councill, lee giles, pradeep teregowda. Ann rose augusthy 1, vipin kv 2, sarath chandran c 2, thushara mv 2, shahin muhammed tk 3. Histopathological evaluation of sheep buccal mucosa, control a, sample buccal mucosa b. For each formulation, three randomly selected patches with surface area 1 cm 2 were used. Formulation and in vitro evaluation of mucoadhesive buccal patches of ondansetron hydrochloride sathish dharani and shayeda vaagdevi college of pharmacy, warangal, india. Formulation and in vitroin vivo evaluation of naproxen.
The backing membrane was prepared by using sodium alginate. Patches with any imperfections, entrapped air, or differing in thickness, weight or content uniformity were excluded from further studies. The prepared buccal films were evaluated for their flexibility, thickness, moisture content, and tensile strength. Formulation and invitro evaluation of mucoadhesive buccal patches of cyproheptadine s. An approach to prepare buccal patches using chitosan and hpmc polymers jose, jobin, charyulu, r. Rjpt formulation and evaluation of mucoadhesive buccal films of losartan potassium besides acting as platforms for sustained release dosage forms, bioadhesive polymers can themselves exert some control over the rate and amount of drug release and thus contribute to the therapeutic efficacy of bioadhesive drug delivery system. The buccal region offers an attractive route of administration for systemic drug delivery. Development and evaluation of buccal film of carvedilol. Jun 09, 2010 the physicomechanical evaluation table ii indicates that the weight variation of these formulated buccal patches varied between 2. Formulation and evaluation of mucoadhesive buccal patches of labetalol.
The formulation of hcz and atn mucoadhesive buccal patch was found to be. Mucoadhesive buccal film of flurbiprofen, formulation and evaluation. This study concludes that mucoadhesive buccal patches that were prepared were safe, convenient and effective formulation for the systemic. Pdf formulation and evaluation of buccal patches for. However, in most of the buccal patches the drug is dispersed within the polymeric matrix bushetti et al. Formulation and evaluation of buccal patches for delivery of atenolol article pdf available in aaps pharmscitech 1.
Formulation and evaluation of buccal patches of salbutamol sulphate. The physicomechanical evaluation table ii indicates that the weight variation of these formulated buccal patches varied between 2. Rjpt formulation and evaluation of mucoadhesive buccal. Buccal formulationbuccal tablets buccal patches most commonly investigated laminates consisting of an dosage form for buccal drug impermeable backing layer, a tablets are small, flat, and oval, drugcontaining reservoir layer, a with a diameter of approximately bioadhesive surface for mucosal 58 mm attachment tablets can be. Sateesh babu abstract mucoadhesive buccal dosage forms are becoming more popular and patient avoidance of first pass metabolism and liver toxicity, etc. Development and evaluation of mucoadhesive buccal patches of flurbiprofen 957 packed in alluminium foil and stored in a glass container till use. The results of swelling index between the range of 30. Formulation and evaluation of buccal patches of diclofenac sodium shubhra pandey abstract. Oct 14, 2012 buccal formulationbuccal tablets buccal patches most commonly investigated laminates consisting of an dosage form for buccal drug impermeable backing layer, a tablets are small, flat, and oval, drugcontaining reservoir layer, a with a diameter of approximately bioadhesive surface for mucosal 58 mm attachment tablets can be. Formulation and evaluation of mucoadhesive buccal patch.
Formulation and evaluation of buccal patches of simvastatin by. Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon ankita saxena. Formulation, in vitro evaluation and kinetic analysis of. Formulation and evaluation of mucoadhesive buccal patches. Formulation and evaluation of mucoadhesive buccal film of lisinopril. The aim of the present study was to develop the mucoadhesive buccal patches of repaglinide by solvent casting method using the polymers like chitosan, pvp k30 and propyleneglycol as plasticiser. Evaluation of a mucoadhesive buccal patch for delivery of. Evaluation was done on the parameters like weight variation, thickness, moisture absorption.
Evaluation of buccal patchesfilms film weight and thickness the weight of each prepared film was. Mucoadhesive patch were weighed individually x 0 and placed separately in 2% agar gel plates and incubated at 370c10c. Formulation and evaluation of mucoadhesive buccal patches of aceclofenac prasanth v. In partial fulfillment of the requirements for the award of degree of master of pharmacy in pharmaceutics submitted by reg. The weight of water required to detach the tablet from porcine buccal mucosa was noted as mucoadhesive strength and experiment was repeated with fresh mucosa in an identical manner. The patch was designed to provide unidirectional drug release, a large contact surface area and good buccal penetration of drug. Development and in vitro evaluation of mucoadhesive. Formulation and evaluation of mucoadhesive drug delivery. The buccal patches were formulated using polymers hpmc e15 and eudragit rl 100 alone and in combination. Shamim qureshi2, jitendra patel3, uttam prasad panigrahi3, i. Physico chemical evaluation of prepared buccal patches. Aceclofenac containing mucoadhesive buccal patches were. Research article design and evaluation of mucoadhesive buccal. The buccal patches were prepared by solvent casting technique.
Research article design and evaluation of mucoadhesive. Formulation and evaluation of mucoadhesive buccal film of. Formulation and evaluation of buccal patches for delivery of atenolol. Table 8 from formulation, development and invitro evaluation. The mucoadhesive strength of patches was measured in triplicate on a modified physical balance fig. Pranitha 2 vaagdevi pharmacy college, bollikunta, warangal, india sri krupa institute of pharmaceuticals sciences, siddipet, a. Formulation and evaluation of mucoadhesive buccal patch of acyclovir utilizing inclusion phenomenon 889 swelling index the swelling index was measured using the diameter method. Abstractthe present study was performed to optimise the formulation of a mucoadhesive buccal patch for insulin nanoparticles nps delivery. Different mucoadhesive polymers, namely polyvinyl alcohol pva, sodium carboxymethyl cellulose nacmc and chitosan of different grade were incorporated into the patches to modify their mucoadhesive properties. Buccal patches offer greater flexibility and comfort than adhesive tablets and a monolayered buccal patch was chosen for development in this study. Formulation and evaluation of metformin hydrochloride.
Design and evaluation of tizanidine buccal mucoadhesive patches. Formulation and evaluation of a bioadhesive patch for. Formulation and evaluation of mucoadhesive buccal patches of resperidone bingi manasa,ganesh kumar gudas 2, n. Formulation and in vitroin vivo evaluation of naproxen mucoadhesive buccal patches. Formulation and evaluation of buccal patches for delivery of. Buccal patches are highly flexible and thus much more readily tolerated by the patient than tablets. Pdf the purpose of this study was to develop and optimize formulations of mucoadhesive patches of terbutaline sulphate. The objective of this study was to develop mucoadhesive buccal tablets of simvastatin using mucoadhesive polymers. Patch thickness was measured using micrometer screw gauge at three different places. College of pharmacy and vocational studies, muzaffarnagar up251001. Formulation and invitro evaluation of mucoadhesive buccal patches containing zolmitriptan using gel forming polymers n. Each patch was weighed individually on an analytical balance shimadzu, japan and the average weights calculated 18 2. International journal of pharma sciences and research ijpsr vol.
Research paper formulation and evaluation of pimozide. Formulation and evaluation of buccal patches of diclofenac. Design and evaluation of tizanidine buccal mucoadhesive. The best mucoadhesive performance and matrix controlled release was exhibited by the formulation fc.
Buccal films are highly flexible and thus much more readily tolerated by the patient than tablets. To overcome the permeation barrier in oral mucosa, the residence time of mucoadhesive buccal patches on the buccal mucosa has been increased to enhance the drug partitioning to the target tissue. Y 1, selvi arunkumar 1, sam t mathew 2, abin abraham 1 1department of pharmaceutics, gautham college of pharmacy, sultanpalya, r. The goal of the present investigation was to design and evaluate mucoadhesive buccal patches of ondansetron hydrochloride ond which is used for nausea and. The thickness of patches was assessed using a micrometer screw gage mitutoyo, japan. Preparation of mucoadhesive buccal patches the buccal patches were prepared by solvent casting technique. Aug 06, 2012 formulation and evaluation of mucoadhesive buccal patches of labetalol. Introduction n pharmaceutical area, patches are gained importance due to novel, patient convenient.
Introduction in recent years, delivery of therapeutic agents through various mucosal routes has gained significant attention owing to their presystemic metabolism or instability in the acidic environment associated with oral administration. The drug containing layer was prepared by using pectin. The swelling index was measured using the diameter method. The new drug delivery systems that have been developed and developing are the mucoadhesive drug delivery systems, drug. Insulin nps were synthesised by an ionic gelation technique using ndi methyl ethyl chitosan cysteine dmeccys as permeation enhancer biopolymer, tripolyphosphate tpp and insulin.
Formulation and evaluation of buccal patches for delivery. For the preparation of patches commonly used technique is solvent casting technique. Formulation and evaluation of pimozide buccal mucoadhesive patches 741 evaluation of the patches formulated patches were subjected to the preliminary evaluation tests. The polymers were dissolved in casting solvent 10 ml and plasticizer 30% were incorporated then calculated amount of drug dissolved in methanol 2. Bilayerd films were prepared by solvent casting technique using different concentration of two polymers namely, sodium alginate and pectin. Formulation and in vitro evaluation of mucoadhesive buccal. Pdf formulation and evaluation of buccal patches of terbutaline. Mucoadhesive drug delivery systems introduction novel drug delivery systems ndds are the system where the man searches for new methods of entry of drugs in to the body in order to show its activity in the body. The effectiveness of a mucoadhesive formulation is greatly determined by the different nature of the polymer composites used. The release kinetics through cellophane membrane was.
The mucoadhesive buccal patches were prepared by solvent casting technique using two different mucoadhesive polymers. Development of mucoadhesive patches for buccal administration of ibuprofen. In 2008, development of mucoadhesive patches for buccal administration of prochlorperazine. The research paper published by ijser journal is about formulation and evaluation of buccal patches of diclofenac sodium 2.
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